In addition, silencing of TRPM2 attenuated glomerular damage, as shown by HE and PAS staining (Figure 4A), and reduced the severity of glomerular sclerosis, tubular damage and interstitial fibrosis as shown by Masson and Sirius staining (Figure 4B–4D), in the kidneys of diabetic mice. This evidence concerns the gene TRPM2 and glomerulosclerosis.