Interestingly, in addition to 133 ZNF-TFs, we found 62 ZAPs and several signaling molecules involved in the antiviral immune response to be activated at gene level together with TET1 and enriched for the KEGG-pathway “HSV-1 infection.” Our findings emphasize the impact of zinc-dependent proteins and their dysregulation in PCa, and indicate a possible herpesvirus-mediated path of TET1 activation. The gene discussed is TET1; the disease is posterior cortical atrophy.