PGF and cancer: Moreover, GSEA of “Oncogenic signature gene sets” representing cellular pathways often dysregulated in cancer [35] on 626 TET1-coactivated genes showed highly significantly enrichments for gene sets related to Kirsten rat sarcoma viral oncogene homolog (KRAS) and TANK Binding Kinase 1 (TBK1), Placental Growth Factor (PGF), Janus Kinase 2 (JAK2), Catenin Beta 1 (CTNNB1) and Vascular Endothelial Growth Factor A (VEGFA) (Additional file 1: Fig. S9 and Additional file 2: Table S8).