The expression of several genes encoding regulators of stem cell pluripotency, including PI3K, ACVR1/2, BMPR1/2, GSK3B, p38, SMARCAD1, SETDB1, JARID2, KAT6A, REST, and RIF1 showed a strong positive correlation with TET1 expression in PCa and were coactivated in TET1-high PCa (Additional file 1: Fig. S10D). This evidence concerns the gene PIK3CA and posterior cortical atrophy.