In this study, three pairs of HCC tissues of which pathological grade including well/moderate/advanced differentiation, along with their adjacent normal tissues, were used for RNA sequencing and we identified a novel HCC-related circRNA, circSLC7A11, originating from exons 8 and 9 of the SLC7A11 gene and with a circBase ID of hsa_circ_0070975. The gene discussed is SLC7A11; the disease is hepatocellular carcinoma.