In the CKD patients, univariate analysis showed that age, systolic pressure, SCr, CD19(+)CD5(+) B cells and CD19(+)CD5(−) B cells were prognostic factors for overall survival, multivariate Cox regression analysis showed that age (HR = 1.088, 95%CI: 1.015–1.166, P = 0.017), SCr (HR = 1.006, 95%CI: 1.001–1.011, P = 0.018) and CD19(+)CD5(+) B cells≤0.03 × 109 /L (HR = 2.303, 95%CI: 1.241–4.273, P = 0.008) were factors significantly associated with a higher risk of all-cause mortality (Table 5). The gene discussed is CD5; the disease is chronic kidney disease.