Elevated MINA53 expression is reported as a poor prognostic indicator, and thereis evidence that MINA53 downregulation impairs the proliferation andsurvival of cancer cells.3−11MINA53 expression is induced by silica particles,suggesting a role for MINA53 in allergen-induced inflammation,12 and, importantly, in the differentiation ofproinflammatory TH17 cells.13 MINA53 isproposed as an important regulator in inflammation and oncology; however,the underlying molecular mechanisms by which MINA53 is linked to diseaseare unclear.11 The gene discussed is RIOX2; the disease is cancer.