In addition to roles in skeletal growth and boneformation,17,18,20,21 NO66 is linked to cancer, though less wellthan MINA53; its geneis overexpressed in some tumor cell lines, such as colorectal andnonsmall-cell lung carcinomas, where NO66 downregulation impairs proliferation,survival, and migration.17,20,22. The gene discussed is RIOX2; the disease is cancer.