RIOX2 and hepatocellular carcinoma: MYC-induced nuclearantigen (MINA53), also known as mineral dust-inducedgene (Mdig) and ribosomal oxygenase 2 (RIOX2), is a JmjC (Jumonji-C)domain-containing 2-oxoglutarate (2OG)-dependent oxygenase localizingto the nucleolus,1 which is transcriptionallystimulated by the oncoprotein c-MYC.2 MINA53 upregulation is linked to solid and hematologicaltumors, including colon, lung, esophageal, gastric, pancreatic, renal,and hepatocellular carcinomas, breast cancer, leukemias, lymphomas/multiplemyelomas, neuroblastomas, and glioblastomas.