In the present study, we used a rat model of inducible hypertension (Cyp1a1Ren2 rat) alongside the well-established surgical model of myocardial infarction (the ligation of the left anterior descending coronary artery) to replicate a more typical clinical scenario, to explore the pathophysiological interactions between hypertension and myocardial infarction on cardiac and kidney structure and function, as well as the effects of mineralocorticoid receptor antagonism. Here, NR3C2 is linked to Hypertension.