NR3C2 and hypertensive disorder: In the present study, we used a rat model of inducible hypertension (Cyp1a1Ren2 rat) alongside the well-established surgical model of myocardial infarction (the ligation of the left anterior descending coronary artery) to replicate a more typical clinical scenario, to explore the pathophysiological interactions between hypertension and myocardial infarction on cardiac and kidney structure and function, as well as the effects of mineralocorticoid receptor antagonism.