TARDBP and amyotrophic lateral sclerosis: We previously examined the diagnostic and prognostic performance of NfL, TDP-43, and t-tau in CSF and plasma as biomarkers of ALS in two individual case-control cohorts, revealing increased levels of CSF NfL, plasma NfL, and CSF TDP-43 in ALS compared with control groups and shorter survival associated with higher levels of CSF and plasma NfL [11].