In addition, analysis of the repeat sequence context showed that the APC indels in the MSH3-deficient adenomas occurred significantly more frequently in a repetitive sequence context than APC indels in adenomas from patients with FAP (p < 0.01), and clearly more frequently than APC indels in adenomas from patients with unexplained polyposis (Fig 3B). The gene discussed is MSH3; the disease is polyposis.