In line with this, we identified the same 1 bp deletion in the 8-bp polyadenine [(A)8] tract in exon 10 of the ACVR2A gene in three adenomas (Table 2), which is a frequent microsatellite indel driver hotspot in colorectal MSI neoplasms [52–54]. The gene discussed is ACVR2A; the disease is adenoma.