The proportion of APC indels was significantly higher in the MSH3-deficient adenomas than that observed in FAP patients (p = 0.003) or in published data on sporadic adenomas (HGCA) (p < 0.0001), and was higher than in adenomas from patients with unexplained polyposis, although the latter did not reach statistical significance, probably due to low numbers of APC variants (Fig 3A). This evidence concerns the gene MSH3 and polyposis.