The mean TMB (2.3 variants/Mb) in the present study was similar to that observed in previous WES analyses of sporadic (0.6–4.6 variants/Mb) and FAP-related (0.2–1.8 variants/Mb) MSS colon adenomas, although the published TMB showed wide variability, probably due to cross-study differences in adenoma size, methodology, and filter criteria [20, 33–38]. The gene discussed is FAP; the disease is adenoma.