Since it harbours coding microsatellites similar to TGFBR2, ACVR2A is one of the most frequently mutated genes in CRC in patients with Lynch syndrome [49, 50] and perturbation of TGFß signalling through truncating variants in ACVR2A is suggested to be an early event in CRC carcinogenesis [43]. The gene discussed is TGFBR2; the disease is Lynch syndrome.