The animals vaccinated with the peptides were not protected, however, they were able to activate the production of IgG type antibodies, with greater predominance in the production of IgG2a by G2, as well as they were also able to activate the production of cytokines such as IL-2, IL- 4, IL-6, IFN-γ, and TNF-α indicating a direction for Th1 type immune response, effective for infection with C. pseudotuberculosis. This evidence concerns the gene IL2 and infection.