TNF and infection: The G6 showed the production of IFN-ɣ, TNF-α, IL-17, IL-4, and IL-6 every 60 days after the challenge with the virulent strain, being more related to the pathogenesis of CLA, which presents a profile of expressed cytokines, where the pro-inflammatory cytokines TNF-α and IFN-ɣ prevail mainly at the infection site [37].