Another study reported that the inhibition of LIMK/cofilin pathway via PAK1 inhibition (i.e., an activator of LIMK), suppresses the growth of several HCC cell lines, which is accompanied by decreased tumor value in vivo, due to the enhancement of apoptosis in relation to the blocked NF-kB activation [41]. This evidence concerns the gene NFKB1 and hepatocellular carcinoma.