When AI-based severity score was added to the model, prior myocardial infarction (OR = 2.81, 95% CI = 1.12–7.04, p = 0.027), immunodeficiency (OR = 2.08, 95% CI = 1.02–4.25, p = 0.043), CRP (OR = 1.73, 95% CI = 1.32–2.33, p < 0.001) and AI-based severity score (OR = 1.08, 95% CI = 1.02–1.15, p = 0.013) proved to be independent predictors of clinical decline. The gene discussed is CRP; the disease is immunodeficiency disease.