Even though most of the snoRNAs appeared to be downregulated, the study showed that a cluster of snoRNAs located at the DLK1-DIO3 locus was overexpressed in samples of acute promyelocytic leukemia (APL) carrying the PML-RARalpha_bcr1 translocation. The gene discussed is DIO3; the disease is acute promyelocytic leukemia.