DNER and cancer: Not surprisingly, BET proteins have been mapped at enhancer sites across the genome [6], are found at important nodes of interaction within the proteome [7], and are implicated in multiple biological processes including: meiosis and germline formation [8,9], homeobox (Hox) gene regulation [10], lineage specification [11,12], hematopoiesis [13], neurogenesis [14], cell cycle progression [15], maintenance of pluripotency [16], and, significantly, disease states such as cancer [17,18], kidney disease [19], metabolic syndrome [20], and neuroinflammation [21].