The thermosensitive poly(D, L-lactide)-poly(ethylene glycol)-poly(D, L-lactide) (PDLLA-PEG-PDLLA, PLEL) triblock copolymer self-assembled into micelles in water and coated with tumor cell lysates, GM-CSF, and TLR9 agonist cytosine-phosphate-guanine oligonucleotide (CpG-ODN) to form a hydrogel vaccine system, which forms a gel at 37 °C. Here, CSF2 is linked to neoplasm.