In the 4T1 tumor and B16 melanoma models, not only the production of IgG and the secretion of cytokines, such as IFN-γ, interleukin-4 (IL-4), and TNF-α, were upregulated; the effector T cell CD8+ was activated, and the number of Tregs was reduced. This evidence concerns the gene IL4 and neoplasm.