The first report on MYCN (as previously was named as myc, n-myc), was by Schwab and Bishop (1988), where they have reported that besides its role in human tumors, it participated in various biological processes, including senescence [5], resistance to therapy [6] and most interestingly it was found that “circular extra-chromosomal DNA molecules could transport amplified MYCN proto-oncogenes in human neuroblastomas” [7]. The gene discussed is MYCN; the disease is neuroblastoma.