G6PC1 and carcinoma: In GSD1a, to maintain blood sugar levels and prevent late-onset complications such as hepatocellular adenoma/carcinoma, a phase I/II clinical trial and long-term study for GSDIa (NCT03517085, NCT03970278) of AVV serotype 8-mediated gene transfer of G6PC (AAV8G6PC) is in progress to evaluate the dosage and safety in adult GSDIa patients.