PSEN2 and Alzheimer disease: Our analyses of young adult brain transcriptomes in zebrafish have found that five EOFAD-like mutations in a total of three EOFAD gene orthologues (psen1, psen2 and sorl1) all cause statistically significant effects on the expression of genes involved in oxidative phosphorylation, whereas non AD-related mutations in psen1 and psen2 do not.