Among our transcriptome analyses of AD models, we only observed statistically significant changes to the expression of genes in the KEGG gene set for mTOR signalling in transheterozygous sorl1 mutants, in psen1Q96_K97del/+ mutant zebrafish after acute hypoxia exposure, and in both male and female APOE4 mice. The gene discussed is APOE; the disease is Alzheimer disease.