We first collated our findings from our zebrafish models of EOFAD-like mutations in psen1 (Barthelson et al., 2021a; Hin et al., 2020, 2021; Newman et al., 2019), psen2 (Barthelson et al., 2021b) and sorl1 (Barthelson et al., 2020b, 2021c). This evidence concerns the gene SORL1 and early-onset autosomal dominant Alzheimer disease.