Alzheimer's disease (AD) is a complex and highly heterogenous neurodegenerative disease, defined by the presence of intracellular neurofibrillary tangles (primarily consisting of hyperphosphorylated tau proteins), and extracellular plaques mostly consisting of a small peptide, amyloid β (Aβ) (Jack et al., 2018). Here, MAPT is linked to Alzheimer disease.