Interestingly, we observed highly statistically significant changes in the gene set ire3_all only in APOE4 male mice, reminiscent of similar signals in some of the young adult EOFAD-related zebrafish (Barthelson et al., 2020b; Hin et al., 2021; Fig. 1B; Fig. S22C) and supporting the existence of iron dyshomeostasis. Here, APOE is linked to early-onset autosomal dominant Alzheimer disease.