APOE and early-onset autosomal dominant Alzheimer disease: The brain transcriptome similarities seen between our single mutation heterozygous EOFAD mutation-like knock-in zebrafish models and the knock-in APOE ε4 mice strongly support the informative value of these models, and imply that heterozygous EOFAD mutation knock-in mouse models offer a path forward, particularly in understanding the earliest molecular events that lead to AD.