Typical manifestations include personality changes and neuropsychological deficits.11 Anti-Ma antibodies are often found in young males with germ cell tumours and are associated with a range of psychiatric manifestations, including obsessive–compulsive disorder, delirium, major depression, personality changes and amnesia.11 Anti-Yo antibodies are mostly found in females with breast or ovarian cancers. This evidence concerns the gene CDR2 and Personality changes.