There was one case report of oral magnesium used to successfully treat DD, without evidence of relapse for 1 month after treatment (Grade C).51 Due to the role of magnesium in inhibiting calcium efflux from cells, it may benefit patients with SERCA2 dysfunction (as in DD).51 However, as reported in the article, it is difficult to ascertain whether oral magnesium can treat DD or whether positive results are due to the clinical course of DD, which may often undergo remission spontaneously.51 The gene discussed is ATP2A2; the disease is dentin dysplasia.