ATP2A2 and dentin dysplasia: The use of diclofenac sodium gel for treatment of DD was described in multiple reports in the literature (Grade C evidence).78, -80 The proposed mechanism of action for this treatment is through COX-2 inhibition, which has the effect of upregulating production of the SERCA2 protein.78 Patients using this treatment experienced moderate to significant clinical improvement of their DD lesions, without any notable side effects.