Compared with tumors with low Hh activity, tumors with high Hh activity showed significantly lower fractions of CD8+ T cells, the major effector for anti‐tumor immune response, especially in CESC (p < 0.01), GBM (p < 0.05), HNSC (p < 0.0001), KIRC (p < 0.0001), LUAD (p < 0.0001), LUSC (p < 0.0001), SKCM (p < 0.0001), and STAD (p < 0.05) (Figure 3C). The gene discussed is CD8A; the disease is neoplasm.