As expected, Hh activity was negatively correlated with at least one of the TME‐related biomarkers (CYT, GEP, IFN‐γ, and APM) in 71.4%(10/14) TCGA cancer types (CESC, GBM, HNSC, KIRC, LIHC, LUAD, LUSC, OV, SKCM, and STAD), consistent with our previous findings that high Hh activity was associated with an immunosuppressive TME in diverse cancers (Figure 3). The gene discussed is IFNG; the disease is cancer.