Major signalling pathways regulated by the interaction of integrins with ECM proteins or cell adhesion molecules are depicted in Figure 7B for BCAM and VCAM1 impinging mainly on TAM and TAT, for laminins interacting with tumour cells, ADI and MESO in (Figure 7C; left panel), for collagens with receptors on ADI, MESO and TAT (Figure 7C; right panel), or fibronectin interacting with TAM and TAT (Figure 7D; left panel), and for vitronectin preferentially signalling to immune cells, ADI and CAF (Figure 7D, right panel). Here, VCAM1 is linked to neoplasm.