Numerous studies suggest that ADI within the omental TME may play an essential role in HGSC progression67 by promoting the homing and invasion of cancer cells, angiogenesis and chemoresistance via the secretion of adipokines, including IL‐6, IL‐8, THF, leptin, adiponectin and resistin.10, 68, 69, 70. This evidence concerns the gene IL6 and cancer.