Previous studies indicate that SPI1 is upregulated and linked with poor prognosis in breast carcinoma,39 while SPI1 inhibits invasion of hepatocellular carcinoma cells via upregulating miR‐615‐5p or suppressing insulin like growth factor 2 expression,40 suggesting its tumour promoting or suppressive roles in a context‐specific way. Here, SPI1 is linked to hepatocellular carcinoma.