Stable over‐expression of SPIB led to elevation in tumour growth, weight, glucose uptake, lactate generation, ATP synthesis, downstream gene expression, Ly6G+ neutrophils, Ki‐67 expression and CD31‐staining microvessel density of cancer cells‐generated hypodermic xenograft models, which was abolished by knockdown of SPI1 (Figures 6I and S8A–C). The gene discussed is SPIB; the disease is neoplasm.