Importantly, upregulation of SPI1 (p = 2.2 × 10−3), HK2 (p = 1.0 × 10−2) or PGK (p = 2.9 × 10−4) was found to be related with a poor survival in colon cancer patients (Figure 1G). Here, HK2 is linked to malignant colon neoplasm.