In vivo tumour growth, weight, glucose uptake, lactate generation, ATP synthesis, downstream gene expression, Ly6G+ neutrophils, Ki‐67 expression and CD31‐staining microvessel density of hypodermic xenograft models generated by cancer cells were enhanced upon stable SPI1 over‐expression, which was prevented by anti‐Ly6G antibody (Figures 3E, F and S5A). Here, PECAM1 is linked to cancer.