HK2 and malignant colon neoplasm: In colon cancer cases, a positive correlation between SPIB and HK2 expression was noted (R = 0.1441, p < 1 × 10−4) or PGK1 (R = 0.3072, p < 1 × 10−4, Figure 8E) and high levels of SPIB (p = 1.5 × 10−2) were linked with poor prognosis of colon cancer patients (Figure 8F).