Of subsets of CD3+ T cells, the frequencies of cluster 06 identified as NKT cell with markers of CD3+ CD3+CD56+CD8a+TCRab+CD45RA+CCR7−CD45RO+Tbet+GranzymeB+ (Table 3) and cluster 12 as CD4+ TCM with markers of CD3+CD4+TCRab+CD45RA−CCR7+CD45RO+CD27+CD127+ significantly decreased in acute pneumonia. The gene discussed is TBX21; the disease is pneumonia.