EPAS1 and nonpapillary renal cell carcinoma: Subsequently, sequencing (Figure 6B) and related expression experiments based on knockdown of HIF2α all indicate that HIF2α positively regulates NUDT1; that is, knockdown of HIF2α can significantly reduce the protein and RNA levels of NUDT1 in ccRCC (Figures 6C, D and S11A, B).