We have previously demonstrated the value of this approach in another translocation-positive sarcoma, alveolar soft-part sarcoma (ASPS), where the ASPL-TFE3 fusion upregulates the MET receptor tyrosine kinase (RTK), creating a targetable dependency on MET signaling (Kobos et al., 2013; Tsuda et al., 2007). Here, ASPSCR1 is linked to alveolar soft part sarcoma.