EWSR1 and sarcoma: Known COSMIC somatic mutations or truncating mutations in tumor suppressor genes as well as copy number variants (CNVs) are listed for each DSRCT cell line in Fig. 3E. Among the notable findings was a STAG2 deletion in one sample, a gene known to be recurrently inactivated in an aggressive subset of ESs (Tirode et al., 2014), another EWSR1-rearranged sarcoma (El Beaino et al., 2020).