Interaction and ratio between proinflammatory cytokines and BDNF are also taken into account, since better understanding of the interaction between proinflammatory cytokines and BDNF is needed and the proinflammatory cytokine/neurotrophin balance may play an important role in brain diseases (Johnson and Sharma, 2003; Lima Giacobbo et al., 2019). This evidence concerns the gene BDNF and brain disorder.