PANX1 and COVID-19: In addition, Panx-1 channel opening is indirectly associated with IL-1β processing and release (Lee et al., 2018; Pelegrin and Surprenant, 2006, 2009; Seil et al., 2010; Yang et al., 2019), suggesting that Panx-1 amplifies inflammation, but its role in COVID-19 pathogenesis is unknown.