PANX1 and COVID-19: More importantly, blocking Panx-1 channel opening reduces Pseudomonas aeruginosa infection and associated inflammation (Maier-Begandt et al., 2021; Wonnenberg et al., 2014), the deleterious effects of smoking (Baxter et al., 2014), cystic fibrosis (Higgins et al., 2015), lung-associated heart failure (Dahl et al., 2016), blood vessel compromise (Luo et al., 2017), ischemia-reperfusion (Kirby et al., 2021; Sharma et al., 2018), coagulation (Taylor et al., 2021), and ventilator-associated damage (Jia et al., 2018), suggesting a potential therapeutic approach for COVID-19.