Subsequently, when we compared the effects of SARS-CoV-2 infection with hCoV-229E viral infection, Panx-1 opening and its sensitivity to furin, ACE-2, and endocytosis were more evident with SARS-CoV-2, suggesting that the S protein of SARS-CoV-2 is not only important for entry but also associated with inflammation and the pathogenesis of the virus. This evidence concerns the gene ACE2 and viral infectious disease.