Panx-1 channels participate in several inflammatory conditions exacerbated during COVID-19 pathogenesis, including hypoxia, coagulation, blood pressure, endothelial permeability, and apoptosis (Abdeen et al., 2021; AbdelMassih et al., 2021; Chang et al., 2020; Contoli et al., 2021; Hertzog et al., 2021; Li et al., 2020; Liu et al., 2020b; Montero et al., 2020; Page et al., 2021; Taz et al., 2021; Toldo et al., 2021; Wang et al., 2020). Here, PANX1 is linked to COVID-19.