Although the significance of IL-18 in aiding dengue illness progression is unknown, it has been observed that IL-18 production is changed in metabolic syndromes [76, 77], hypertension [78], diabetic patients [79], cardiovascular disorders [80], atherosclerosis [80, 81], and also several flavivirus infections such as JEV [82], tick-borne encephalitis virus (TBEV) [83], and ZV infection [84, 85]. This evidence concerns the gene IL18 and hypertensive disorder.