BRAF may play an important role in this relationship, because it is believed that the presence of BRAF V600E mutation is associated with the deletion of Rap1GAP allele and changes in protein expression [13], while hiSTONE deacetylation of NIS promoter is the basis of BRAF V600E promoting NIS silencing in thyroid cancer [28]. This evidence concerns the gene SLC5A5 and thyroid cancer.