FRS2 and cancer: The five selected KEGG pathways and their corresponding genes were as follows: mitogen-activated protein kinase (MAPK) signaling pathway (Mapk14, Map3k12, and Rps6ka4), thermogenesis (Mapk14, Frs2, Prkab2, and Uqcrh), proteoglycans in cancer (Mapk14, Frs2, and Lum), Salmonella infection (Mapk14, Arpc5, and Wasf2), and neurotrophin signaling pathway (Mapk14, Frs2, and Shc3).