Using RNA sequencing combined with single-cell proteomics, one research group determined that elevated frequency of HLA-DRhiCD11chi inflammatory monocytes with an IFN-stimulated gene signature was found in mild COVID-19, whereas severe COVID-19 was characterized by the occurrence of neutrophil precursors, as evidence of emergency myelopoiesis, dysfunctional mature neutrophils, and HLA-DRlo monocytes [57]. The gene discussed is IFNA1; the disease is COVID-19.