The KEGG pathway analysis shows that pathways affected by PBDEs mainly involve the pathways in cancer, proteoglycans in cancer, progesterone-mediated oocyte maturation, PI3K-Akt signaling pathway, hepatitis C, thyroid hormone signaling pathway, prolactin signaling pathway, thyroid cancer, MAPK signaling pathway, and others. This evidence concerns the gene AKT1 and thyroid gland carcinoma.