Using TCGA database for prognosis analysis to investigate the effect of core genes on gastric cancer prognosis, survival analysis showed that the total survival of patients with high gene expression of IL-6, COL1A1, PTGS2, SELE, VCAM1, and SERPINE1 was lower than that of low expression patients, the difference was statistically significant (log-rank P < 0.05), and the difference in the results of other genes was not statistically significant (Figure 9). The gene discussed is SERPINE1; the disease is gastric cancer.