Spontaneous uveitis development was associated withincreased populations of Th17 cells in the intestinal lamina propria.[32] This supports the findings indepleted R161H and GF R161H where clinical manifestation and Th17 cells of the laminapropria is reduced.[19,32] In an earlier study by Horai et al,it is recognized that T-cell activation in the intestine is independent of endogenousIRBP expression.[32] They crossedR161H mice to Rbp3–/– mice, which lack IRBP expression. Here, RBP3 is linked to uveitis.