The hypothesis of testing the effect of the IL4 rs2070874 and FOXP3 rs3761548 polymorphisms in the predisposition to KC development is based on the fact that these polymorphisms known to be associated with allergies could be either directly associated with the development of KC or indirectly, via inflammation induced by micro-trauma due to eye rubbing.[34] Indeed, our results [Table 1] showed that atopy and eye rubbing in patients with KC were significantly associated with the pathology in our study sample (P= 1×10-6) [Table 1]. This evidence concerns the gene FOXP3 and keratoconus.