Thus, Tregs mediate dominant tolerance to self and have also been shown to be equally important in the control of autoimmune diseases, allergy, fetal–maternal tolerance, allograft tolerance, and immunopathology.[16] The rs3761548 polymorphism of FOXP3 gene was identified as being associated with AR in heterozygous form in Han Chinese patients,[17] and in Hungarian AR patients.[18]. Here, FOXP3 is linked to allergic disease.