Increasing numbers of researchers have shown that necroptosis, a new concept of necrosis, is regulated by the RIP kinase family, including receptor interacting protein 3 (RIP3) and downstream molecule lineage kinase domain-like protein (MLKL), which are involved in the regulation of several inflammatory processes, including myocardial infarction [9], ischemia-reperfusion injury [10], inflammatory bowel disease [11], and chronic obstructive pulmonary disease [12]. This evidence concerns the gene RIPK3 and chronic obstructive pulmonary disease.