NOS3 and endothelial dysfunction: Astragaloside IV improves oxidative stress-mediated endothelial dysfunction mainly by reducing the ROS that induce oxidative stress, preventing or reversing the uncoupling of eNOS, and increasing eNOS and NO and a variety of activating enzymes to activate the antioxidant system and other molecular mechanisms, which are clinical vascular endothelial dysfunction diseases provide a certain basis.