TP53 (56%), TTN (23%), CSMD3 (8%), MUC16 (7%), FLG (6%), FAT3 (6%), DNAH3 (5%), SYNE1 (5%), USH2A (5%), and HMCN1 (4%) were the most frequently mutated genes across ovarian cancer. The gene discussed is MUC16; the disease is ovarian cancer.