Mutation in the p53 gene through different signaling pathways causes more expression of cytoplasmic transporters of GLUT1, 2, 3, and 4 and the inhibition of pyruvate dehydrogenase kinase 2 expression in order to increase glucose consumption and the production of metabolites for proliferation from pathways such as the pentose phosphate pathway to the progression of cancer [2, 6]. The gene discussed is PDK2; the disease is cancer.