10 genes are upregulated (CASP8, NOD1, GPX4, CASP4, PJVK, IL6, IL1B, PLCG1, NOD2, and GSDMC) and 13 downregulated (ELANE, CASP5, NLRP7, IL18, NLRP3, NLRC4, PRKACA, NLRP1, GSDMB, CASP9, CASP3, TIRAP, and NLRP2) in tumor tissues. The gene discussed is GPX4; the disease is neoplasm.