In order to further explore the value of the two MCs, we constructed a 13-gene signature based on DEGs of MCs (KIF7, SYNGR3, NCKAP5L, ZKSCAN2, SIX2, OLFM2, GPSM1, ZEB1-AS1, CD72, TGFB2, CSRP2, TRPV4, and LHX6). Kinesin superfamily (KIF) has a long-reported significant influence on the initiation, development, and progress of cancer. Here, SIX2 is linked to cancer.