Hence, the purpose of the present study was to evaluate the GCF levels of the NLRP3 inflammasome and its components in patients with P and CHC and to determine if its upregulation is influenced by these joined pathologies, periodontitis, and chronic hepatitis C, leading to a more exacerbated manifestation of periodontal disease in CHC patients. This evidence concerns the gene NLRP3 and periodontal disorder.