IL1A and periodontitis: Our previously published study, focusing on the gingival crevicular fluid (GCF) assessment of interleukin-1alpha's and interleukin-1beta's involvement in the pathogenic process of periodontitis patients with chronic hepatitis C, highlighted a significantly worsened periodontal status and increased levels of these cytokines in patients with both diseases, as compared to those of nonhepatitis C patients suffering from periodontitis [17].