The results of this study suggest that the three major tumors reported in Trp53 KO mice can be successfully induced by TALEN-mediated deficiency of the Trp53 gene in FVB/N-Trp53em2Hwl/Korl KO mice, although only C57BL/6-Trp53em1Hwl/Korl KO mice showed malignant lymphoma. The gene discussed is TP53; the disease is lymphoma.