Renal histopathology showed minimal change disease (MCD) in 6 patients (75%) (2 classic MCD, 1 MCD with mesangial expansion, 2 MCD with IgM deposits, 1 MCD with C1q deposits) and focal segmental glomerulosclerosis (FSGS) in 2. The gene discussed is CD40LG; the disease is focal segmental glomerulosclerosis.