Interestingly, for BVDV-1 strain NADL and BVDV-2 strain CS8644, trans-complementation with CD46-CTS enabled a more efficient infection than CD46-CTL, with approx. three-fold (NADL) and six-fold (CS8644; ***p < 0.001) increased titres in comparison to MDBK WT cells. This evidence concerns the gene CD46 and infection.