IFNG and Hepatic fibrosis: Here we showed that MALAT1 expression was increased in macrophages isolated from in vivo CCl4-induced liver fibrosis or those treated in vitro with M1 stimuli, LPS or IFNγ, which was associated with the up-regulations of multiple pro-inflammatory cytokines and the activation of NLRP3 inflammasome-induced pyroptosis, supporting the involvement of MALAT1 in M1 polarization and pyroptosis of macrophages, as well as the link between these two processes.