IFNG and Hepatic fibrosis: In addition to examining MALAT1 and METTL3 expressions using the in vivo liver fibrosis model, we also established an in vitro model where macrophages were treated with IFN-γ or LPS to induce M1 polarization, which are well demonstrated to promote the productions of pro-inflammatory cytokines, activate HSCs, and stimulate liver fibrosis [7, 17].