To verify the participation of FGF2 and ACLY in ONECUT2-mediated HCC metastasis, we knocked down FGF2 and ACLY in ONECUT2-overexpressing PLC/PRF/5 cells, and upregulated FGF2 and ACLY in ONECUT2-silencing MHCC97H cells (Supplementary Fig. S5 and Fig. 4A). This evidence concerns the gene HSPG2 and hepatocellular carcinoma.