DNA damage induced by chemotherapeutic agents and ionizing radiation promotes the translocation of NAT10 from the nucleolus to nucleoplasm, facilitating the acetylation of MORC2 at evolutionarily conserved lysine 767 (K767Ac) and resulting in DNA damage-induced reduction in H3T11P expression and transcriptional repression of the downstream target genes CDK1 and Cyclin B1, thus resulting in DNA damage-induced G2 checkpoint activation and cell survival in breast cancer [55]. Here, MORC2 is linked to breast carcinoma.