HDAC4 and gastric neoplasm: For instance, MORC2 binds to carbonic anhydrase IX (CAIX) and recruits histone deacetylase 4 (HDAC4), which deacetylates of histone H3 at the promoter and represses the transcription of the CAIX gene; this gene plays a key role in gastric tumor cell growth and survival [39].