HECW2 and chronic pancreatitis: However, MORC4 and CLDN2 have been specifically indicated as having a significant association with chronic pancreatitis, in which the downstream signaling of MORC4 activation might be interact with proteins known to be associated with chronic pancreatitis, including AMPKa1, GEMIN4, HECW2, SKIL, STAT3, and UBC [90].