ERBB2 and colorectal carcinoma: Consistent with the findings in CRC cells, when compared with matched adjacent tissues, HER2 was expressed at significantly high levels in total, primary (I/II) or metastatic (III/IV) CRC tissues (P < 0.001) (Fig. 2A–C and Figs. S1–S5), which was also consistent with the results of others [24, 25].