SLC25A1 and colorectal carcinoma: As shown in Fig. 6C, CRC cells transfected with empty vector (EV) under energy stress (absence of glucose in cell culture medium) showed a significant increase in cell apoptosis compared with CRC cells transfected with empty vector (EV) in the presence of glucose, while overexpression of SLC25A1 significantly attenuated energy stress-induced cell apoptosis.