PSMD3 was involved in “Cell cycle_Role of Nek in cell cycle regulation”, “Transcription_Negative regulation of HIF1A function”, “DNA damage_Intra S-phase checkpoint”, “DNA damage_ATM/ATR regulation of G2/M checkpoint: cytoplasmic signaling”, “Cytoskeleton remodeling_Keratin filaments”, and “Regulation of degradation of deltaF508-CFTR in CF” (Figure 11 and Supplementary Table 4). Here, ATR is linked to cystic fibrosis.